Setien was appointed on Monday following the sacking of Ernesto Valverde, though he has resisted any urge to make wholesale changes.
Barca’s last outing saw them lose 3-2 to Atletico Madrid in the Supercopa de Espana semi-final, with Lionel Messi, Antoine Griezmann and Luis Suarez leading the line.
But since then Suarez has been ruled out for most of the season after having knee surgery, resulting in a rethink in attack.
The one to benefit from Suarez’s absence is 17-year-old Fati, who broke into the first-team squad at the start of the season.
Marc-Andre ter Stegen returns in goal following a spell out with a knee injury, while the much-maligned Ivan Rakitic takes the place of the suspended Frenkie de Jong in midfield.
Setien’s arrival was seen as a positive for the club’s promising youngsters, with the likes of Riqui Puig – who hardly had a look-in under Valverde – brought to train with the senior side straight away.
Puig, 20, is among the substitutes at Camp Nou, as is fellow La Masia product Carles Perez.
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